Shen Yan-hong, Chen Feng, Huang Man-ni, Liu Bin, Wang Xi-xia, Zhao Fang-hui, Li Shu-min, Li Nan, Wu Ling-ying, Rong Shou-de, Zhang Wen-hua, Ren Sheng-da, Huang Rui-de, Qiao You-lin
Department of Epidemiology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Aug;25(4):381-5.
To investigate the prevalence of oncogenic type of human papillomavirus (HPV) infection and identify the high risk population for conducting immuno/chemoprevention of cervical cancer.
All married women aged 30 to 50 with no history of hysterectomy, pelvic radiation and non-pregnant from certain villages of Xiangyuan and Yangcheng County were invited. This study was conducted through two phases. In phase one, subjects sampled the vaginal secretions using the collectors after signing the informed consent. And physicians sampled exfoliated cells from cervix in the phase two. All the specimens were tested with the Hybrid Capture 2 test. The data was managed and analyzed by VFP and SPSS software.
There were 9,683 women participated in this study. Local women welcomed this study and population compliance rate was 75.4%. In tested population, we found 2,666 subjects of HPV DNA positive and HPV prevalence was 27.5%. The rates of different age group were 24.5% (30-34 yrs), 27.4% (35-39 yrs), 28.2% (40-44 yrs), 27.4% (45-50 yrs) respectively and had no significant differences (P = 0.604). The rates were slightly increased with the higher education level and had no differences (P = 0.106). The rate in mountain areas was higher than that in half-mountain areas (P = 0.001).
The prevalence of HPV infection is indeed high in this region. Local women and health professionals welcome the activities of cervical cancer screening and prevention. It is an emergent task to improve their sanitary condition and prevent them from cervical cancer in these women. A women health cohort is established successfully among high HPV exposed women in rural China. The extensive biologic specimen repository has been successfully established to simultaneously study the etiology, early detection, and immuno/chemoprevention of cervical cancer.
调查致癌型人乳头瘤病毒（HPV）感染的流行情况，并确定宫颈癌免疫/化学预防的高危人群。
邀请了襄垣县和阳城县某些村庄所有年龄在30至50岁之间、无子宫切除史、无盆腔放疗史且未怀孕的已婚妇女。本研究分两个阶段进行。在第一阶段，受试者签署知情同意书后使用采集器采集阴道分泌物。在第二阶段，医生采集宫颈脱落细胞。所有标本均采用杂交捕获2试验进行检测。数据由VFP和SPSS软件进行管理和分析。
共有9683名妇女参与本研究。当地妇女对本研究表示欢迎，人群依从率为75.4%。在检测人群中，我们发现2666名受试者HPV DNA呈阳性，HPV感染率为27.5%。不同年龄组的感染率分别为24.5%（30 - 34岁）、27.4%（35 - 39岁）、28.2%（40 - 44岁）、27.4%（45 - 50岁），差异无统计学意义（P = 0.604）。感染率随教育程度升高略有增加，但差异无统计学意义（P = 0.106）。山区的感染率高于半山区（P = 0.001）。
该地区HPV感染率确实较高。当地妇女和卫生专业人员对宫颈癌筛查和预防活动表示欢迎。改善这些妇女的卫生状况并预防她们患宫颈癌是一项紧迫任务。在中国农村高HPV暴露妇女中成功建立了一个女性健康队列。已成功建立了广泛的生物标本库，以同时研究宫颈癌的病因、早期检测以及免疫/化学预防。
