Dong Jian-qun, Zhang Qing-hua, Jiang Zhi-xin, Yi Zhi-yong, Yu Lu, Li Zhen-hua, Zhang Yan-qin, Fang Ming-jun, Zhang Zhen-xin, Zhang Kong-lai
School of Basic Medicine, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing 100005, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jul;24(7):604-7.
To explore the association with cigarette smoking for Parkinson's disease (PD).
One hundred and fourteen PD cases and 205 controls matched on gender and race were recruited from ongoing PD prevalence survey and identified at the neurological clinic of Peking Union Medical College Hospital. Face to face questionnaire interview was carried out and data on smoking and alcohol consumption were analyzed in a population-based case control study.
With never-smokers as the reference category, we observed reduced risk for PD among ever smokers (OR = 0.49, 95% CI: 0.30 - 0.79) current smokers (OR = 0.44, 95% CI: 0.23 - 0.86) and ex-smokers (OR = 0.54, 95% CI: 0.30 - 0.96). When comparing with non-smokers, the ever smokers stratified by years of smoking had an inverse association with those whose smoking history longer than 20 years (OR = 0.35, 95% CI: 0.18 - 0.70) and an mild protective association with those who smoked less than 20 years (OR = 0.61, 95% CI: 0.35 - 1.07). Those who had quitted smoking for more than 20 years were less likely to have the disease than never smokers, and those who had quitted for less than 20 years were least likely to have PD. Those current smokers were still least likely to have the disease. Significant inverse gradient with pack-day smoker (trend P < 0.05), and the inverse association for cigarette smoking and PD were found not bing confounded by alcohol consumption.
The inverse association between PD and cigarette smoking and history of cessation was found. Further studies need to provide biochemical evidence on the relation between smoking and its protective effect on PD.
探讨帕金森病（PD）与吸烟之间的关联。
从正在进行的PD患病率调查中招募了114例PD患者和205例按性别和种族匹配的对照，这些患者在北京协和医院神经科门诊确诊。在一项基于人群的病例对照研究中，进行了面对面问卷调查，并对吸烟和饮酒数据进行了分析。
以从不吸烟者作为参照类别，我们观察到曾经吸烟者（比值比[OR]=0.49，95%可信区间[CI]：0.30 - 0.79）、当前吸烟者（OR = 0.44，95% CI：0.23 - 0.86）和既往吸烟者（OR = 0.54，95% CI：0.30 - 0.96）患PD的风险降低。与不吸烟者相比，按吸烟年限分层的曾经吸烟者中，吸烟史超过20年者与之呈负相关（OR = 0.35，95% CI：0.18 - 0.70），吸烟少于20年者与之呈轻度保护关联（OR = 0.61，95% CI：0.35 - 1.07）。戒烟超过20年者患该病的可能性低于从不吸烟者，戒烟少于20年者患PD的可能性最小。当前吸烟者患该病的可能性仍然最小。与每日吸烟量呈显著负梯度（趋势P<0.05），且发现吸烟与PD之间的负相关不受饮酒的混杂影响。
发现PD与吸烟及戒烟史之间存在负相关。进一步研究需要提供吸烟与其对PD保护作用之间关系的生化证据。
