Kuznetsov V A, Makalkin I A
Biofizika. 1992 Nov-Dec;37(6):1063-70.
Mathematical model of the immune response of the cytotoxic lymphocytes to the nonexponentially growing immunogenic tumour has been studied. Local and global biffurcations for realistic values of the parameters were determined. The connection of the oncoimmunological "anomalous" phenomena (immunostimulation of tumour growth, "sneaking through" of tumour, formation of the tumour "dormant" state) has been shown. The probability of manifestation of these effects in vivo was estimated.
研究了细胞毒性淋巴细胞对非指数生长的免疫原性肿瘤的免疫反应的数学模型。确定了参数实际值的局部和全局分岔。揭示了肿瘤免疫学“异常”现象(肿瘤生长的免疫刺激、肿瘤的“逃逸”、肿瘤“休眠”状态的形成)之间的联系。估计了这些效应在体内表现的概率。