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[细胞毒性淋巴细胞与肿瘤细胞相互作用数学模型的分岔分析。肿瘤生长的免疫放大作用及其与肿瘤免疫学其他“异常”现象的相互联系]

[Bifurcation analysis of a mathematical model of the interaction of cytotoxic lymphocytes with tumor cells. The effect of immunologic amplification of tumor growth and its interconnection with other "anomolous" phenomena of oncoimmunology].

作者信息

Kuznetsov V A, Makalkin I A

出版信息

Biofizika. 1992 Nov-Dec;37(6):1063-70.

PMID:1298347
Abstract

Mathematical model of the immune response of the cytotoxic lymphocytes to the nonexponentially growing immunogenic tumour has been studied. Local and global biffurcations for realistic values of the parameters were determined. The connection of the oncoimmunological "anomalous" phenomena (immunostimulation of tumour growth, "sneaking through" of tumour, formation of the tumour "dormant" state) has been shown. The probability of manifestation of these effects in vivo was estimated.

摘要

研究了细胞毒性淋巴细胞对非指数生长的免疫原性肿瘤的免疫反应的数学模型。确定了参数实际值的局部和全局分岔。揭示了肿瘤免疫学“异常”现象(肿瘤生长的免疫刺激、肿瘤的“逃逸”、肿瘤“休眠”状态的形成)之间的联系。估计了这些效应在体内表现的概率。

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