[Results of the treatment of acute gonorrhea with spectinomycin. Comparison with the combination of aqueous penicillin and probenecid].

Results following treatment of acute gonorrhea with aqueous penicillin combined with probenecid and spectinomycin hydrochloride (2.0 g) are compared and found to be statistically equivalent. Therefore, if a patient is allergic to penicillin, spectinomycin hydrochloride can be regarded as a valuable alternative. The results appear to be the same whether probenecid is administered simultaneously or 1/2-2 h before penicillin. It is advisable to control all patients one week after therapy. A second control after 2 weeks for men and after the next menstruation for women is highly desirable. If the patient fails to respond to treatment, not only an increase in the antibiotic dose, but also prolongation of therapy by administering the same dose on 3 consecutive days, is effective.