Noguchi K, Ojiri Y, Chibana T, Sakanashi M
Department of Pharmacology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Arch Int Pharmacodyn Ther. 1992 Nov-Dec;320:68-80.
Renal hemodynamic effects of the angiotensin-converting enzyme inhibitor enalapril diacid (30 micrograms/kg, i.v.; n = 8) were examined using laser-Doppler flowmetry in anesthetized dogs. Two laser-Doppler flowmetry probes were applied simultaneously to measure the renal blood flow of the outer and inner cortex. Changes in cortical renal blood flow, obtained by the laser-Doppler flowmetry method, were intimately related to those in total renal blood flow measured with the electromagnetic flow probe during occlusion of the abdominal aorta or after administration of angiotensin II, norepinephrine, acetylcholine or dopamine. Enalapril diacid produced a significant increase in total renal blood flow, despite moderate hypotension. The blood flow of the inner cortex significantly increased by 21% following enalapril diacid, while that of the outer cortex did not. These data indicate that there may be a regional difference in the intrarenal vasodilating effect of enalapril diacid. These results also demonstrate that the laser-Doppler flowmetry method is suitable for the continuous measurement of directional changes in both outer and inner cortical blood flows.
在麻醉犬中，使用激光多普勒血流仪研究了血管紧张素转换酶抑制剂依那普利二酸（30微克/千克，静脉注射；n = 8）对肾血流动力学的影响。同时应用两个激光多普勒血流仪探头来测量肾外皮质和肾内皮质的肾血流量。在腹主动脉阻断期间或给予血管紧张素II、去甲肾上腺素、乙酰胆碱或多巴胺后，通过激光多普勒血流仪方法获得的皮质肾血流量变化与用电磁血流探头测量的总肾血流量变化密切相关。尽管出现中度低血压，但依那普利二酸使总肾血流量显著增加。依那普利二酸使肾内皮质血流量显著增加21%，而肾外皮质血流量未增加。这些数据表明依那普利二酸的肾内血管舒张作用可能存在区域差异。这些结果还表明，激光多普勒血流仪方法适用于连续测量肾外皮质和肾内皮质血流的方向变化。
