Masnatta L D, Rubio M C
Department of Biopharmacy and Bioavailability, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Eur J Drug Metab Pharmacokinet. 1992 Oct-Dec;17(4):247-50. doi: 10.1007/BF03190155.
Acute clenbuterol administration (50 micrograms/kg, i.v.) to anesthetized normotensive rats, produce a marked reduction in the mean blood pressure, (MBP), about 58 mm Hg. Indocyanine Green clearance analysis (control, 1.83 +/- 0.15: clenbuterol, 1.10 +/- 0.20 ml/min/100 g, P < 0.05) showed that the action in the hepatic vascular bed is opposite to its systemic vasodilator effects. The hepatic blood flow (HBF) appears significantly reduced (control, 8.24 +/- 0.35: clenbuterol, 3.83 +/- 0.71 ml/min/100 g, P < 0.05) whereas the hepatic uptake and excretion proceedings were apparently not affected (control hepatic extraction coefficient, 0.225 +/- 0.024: clenbuterol, 0.300 +/- 0.04, NS). These findings show that a marked reduction in HBF follows systemic vasodilator effects produced by clenbuterol.
对麻醉的正常血压大鼠静脉注射急性剂量的克伦特罗（50微克/千克），可使平均血压（MBP）显著降低约58毫米汞柱。吲哚菁绿清除率分析（对照组，1.83±0.15：克伦特罗组，1.10±0.20毫升/分钟/100克，P<0.05）表明，其对肝血管床的作用与其全身血管舒张作用相反。肝血流量（HBF）显著降低（对照组，8.24±0.35：克伦特罗组，3.83±0.71毫升/分钟/100克，P<0.05），而肝脏摄取和排泄过程显然未受影响（对照组肝脏提取系数，0.225±0.024：克伦特罗组，0.300±0.04，无显著性差异）。这些发现表明，克伦特罗产生全身血管舒张作用后，肝血流量显著降低。
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