Munakata M, Hang C, Masaki Y, Ukita H, Kawakami Y
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Dec;30 Suppl:82-5.
Recently, the role of activated T-cell derived cytokines in the pathophysiology of asthma has been recognized. In this study, we evaluated the effects of interleukin-2 (IL-2) and gamma interferon (IFN-gamma) on contractile and relaxing responses of guinea-pig tracheal strips in isometric tension measurement system. IL-2 enhanced carbachol (Carb)- and KCl-induced contraction, and attenuated isoproterenol (Iso)-induced relaxation. IFN-gamma had little effect on Carb and KCl contraction, but enhanced Iso relaxation. These effects of cytokines were abolished by denuding epithelium from tracheal strips. These results suggest that IL-2 and IFN-gamma are able to affect functions of non-immune cells in the airway, and that the airway epithelium has some role in the effects of cytokines on airway responses.
最近，活化T细胞衍生细胞因子在哮喘病理生理学中的作用已得到认可。在本研究中，我们在等长张力测量系统中评估了白细胞介素-2（IL-2）和γ干扰素（IFN-γ）对豚鼠气管条收缩和舒张反应的影响。IL-2增强了卡巴胆碱（Carb）和氯化钾（KCl）诱导的收缩，并减弱了异丙肾上腺素（Iso）诱导的舒张。IFN-γ对Carb和KCl收缩作用不大，但增强了Iso舒张。通过去除气管条的上皮细胞，细胞因子的这些作用被消除。这些结果表明，IL-2和IFN-γ能够影响气道中非免疫细胞的功能，并且气道上皮细胞在细胞因子对气道反应的影响中起一定作用。
