Loche S, Pintus S, Carta D, Muntoni A C, Congiu G, Civolani P, Pintor C
Servizio di Endocrinologia Pediatrica, Ospedale Microcitemico, Cagliari, Italy.
Acta Endocrinol (Copenh). 1992 Feb;126(2):124-7. doi: 10.1530/acta.0.1260124.
We have evaluated the effect of acute administration of atenolol, a selective beta-adrenergic antagonist, on the GH response to GHRH in nine obese children and in eight age-matched controls. The GH response to GHRH (1-29, 1 microgram/kg iv), evaluated both as the GH peak and as integrated area under the curve, was significantly lower in the obese children than in the controls. Pretreatment with atenolol (50 or 100 mg orally in subjects with body weight less than or greater than 40 kg, respectively, administered 120 min before the GHRH injection) significantly increased the GH response to GHRH in the obese subjects, such that their mean peak GH levels and mean integrated area under the curve after atenolol plus GHRH were similar to those of the control children after GHRH. Also in control children, atenolol caused a significant augmentation of the GH response to GHRH. Mean peak GH levels and mean integrated area under the curve after atenolol plus GHRH were significantly higher in the controls than in the obese children given the same treatment. These data show that inhibition of central beta-adrenergic receptors counteracts the blunted GH response to GHRH present in the obese children. In view of the alleged mechanism of action of beta-adrenergic blockade (inhibition of endogenous SRIH release), our data suggest that the somatostatinergic system is intact in obesity, and that the suppressed GH secretion is due to other causes.
我们评估了急性给予阿替洛尔（一种选择性β-肾上腺素能拮抗剂）对9名肥胖儿童和8名年龄匹配的对照儿童生长激素（GH）对生长激素释放激素（GHRH）反应的影响。以GH峰值和曲线下积分面积评估，肥胖儿童对GHRH（1 - 29，1微克/千克静脉注射）的GH反应显著低于对照组。在注射GHRH前120分钟分别给予阿替洛尔（体重小于或大于40千克的受试者分别口服50或100毫克）预处理，显著增加了肥胖受试者对GHRH的GH反应，使得他们在阿替洛尔加GHRH后的平均峰值GH水平和平均曲线下积分面积与对照儿童在GHRH后的相似。同样在对照儿童中，阿替洛尔也显著增强了对GHRH的GH反应。在给予相同治疗后，对照儿童在阿替洛尔加GHRH后的平均峰值GH水平和平均曲线下积分面积显著高于肥胖儿童。这些数据表明，抑制中枢β-肾上腺素能受体可抵消肥胖儿童中存在的对GHRH的GH反应迟钝。鉴于β-肾上腺素能阻滞剂的所谓作用机制（抑制内源性生长抑素释放），我们的数据表明，肥胖患者的生长抑素能系统是完整的，且生长激素分泌受抑制是由其他原因导致的。
