Aquino-Cias J, Aneiros-Riba R, Hernandez-Mesa N
Physiol Bohemoslov. 1976;25(1):66-9.
Cortical spreading depression (CSD) has been employed in unanesthetized curarized rats, in order to analyse the role of the cerebral cortex in the generation of epileptic self-sustained parozysms produced by direct cortical electrical stimulation. CSD was preferred because it is reversible and may be repeated several times in the same animal. CSD evoked in the hemisphere contralateral to the stimulated cortex decreased the duration of the afterdischarge by 40% and modified its form and amplitude both at the cortical and reticular levels. The possible role of cortical and subcortical structures in the development of after-discharges is discussed.
为了分析大脑皮层在由直接皮层电刺激产生的癫痫性自持发作的发生过程中的作用，在未麻醉的箭毒化大鼠中采用了皮层扩散性抑制（CSD）。选择CSD是因为它是可逆的，并且可以在同一只动物中重复多次。在受刺激皮层对侧的半球诱发的CSD使后放电的持续时间缩短了40%，并在皮层和网状水平上改变了其后放电的形式和幅度。本文讨论了皮层和皮层下结构在后继放电发展过程中的可能作用。
