[亮氨酸31，脯氨酸34]神经肽Y，一种麻醉大鼠中神经肽Y受体的选择性功能性接头后激动剂。

[Leu31, Pro34] NPY, a selective functional postjunctional agonist at neuropeptide-Y receptors in anaesthetised rats.

作者信息

Potter E K, McCloskey M J

机构信息

Prince of Wales Medical Research Institute, School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.

出版信息

Neurosci Lett. 1992 Jan 6;134(2):183-6. doi: 10.1016/0304-3940(92)90512-6.

DOI:10.1016/0304-3940(92)90512-6

PMID:1317023

Abstract

Neuropeptide Y (NPY), a sympathetic cotransmitter, has both prejunctional and postjunctional actions in the cardiovascular system. In the bioassay system used here NPY attenuates cardiac vagal action (an indicator of prejunctional or Y2 action) and increases blood pressure (an indicator of postjunctional or Y1 action). [Leu31,Pro34]NPY has little or no prejunctional activity i.e. does not attenuate cardiac vagal action, but increases blood pressure as effectively as NPY. [Leu31,Pro34]NPY can therefore be used in functional experiments to distinguish between the two types of NPY receptor.

摘要

神经肽Y（NPY）作为一种交感神经共同递质，在心血管系统中具有节前和节后作用。在此处使用的生物测定系统中，NPY减弱心脏迷走神经作用（节前或Y2作用的指标）并升高血压（节后或Y1作用的指标）。[Leu31，Pro34]NPY几乎没有或没有节前活性，即不减弱心脏迷走神经作用，但升高血压的效果与NPY相同。因此，[Leu31，Pro34]NPY可用于功能实验，以区分两种类型的NPY受体。