Wilkins J N, Gorelick D A, Nademanee K, Taylor A, Herzberg D S
Substance Abuse Service, West Los Angeles Veterans Administration Medical Center, Brentwood Division, California 90073.
Recent Dev Alcohol. 1992;10:57-71. doi: 10.1007/978-1-4899-1648-8_3.
This chapter examines the neuroendocrine effects of acute exposure to and withdrawal from alcohol and cocaine, with special emphasis on the hypothalamic-pituitary-adrenal (HPA) axis. We present the results from two preliminary controlled inpatient studies that document HPA dysfunction during acute exposure to alcohol and cocaine and during withdrawal from alcohol. We discuss the methodological approach of these studies in comparison to related attempts in the literature to use measures of thyroid and prolactin regulation to predict risk of relapse to alcohol and cocaine use, respectively. Our data and the results of related studies are presented in the context of a proposed index of HPA axis dysfunction that may provide a useful clinical measure of susceptibility to relapse during protracted abstinence from alcohol or cocaine.
本章探讨急性接触酒精和可卡因以及戒断酒精和可卡因所产生的神经内分泌效应，特别着重于下丘脑-垂体-肾上腺（HPA）轴。我们展示了两项初步的对照住院研究结果，这些结果证明了在急性接触酒精和可卡因期间以及戒酒期间HPA功能障碍。我们将这些研究的方法与文献中相关尝试进行比较，后者分别使用甲状腺和催乳素调节指标来预测酒精和可卡因使用复发的风险。我们的数据以及相关研究结果是在一个拟议的HPA轴功能障碍指数背景下呈现的，该指数可能为长期戒酒或戒毒期间复发易感性提供一个有用的临床指标。
