Toftager-Larsen K, Hørding U, Dreisler A, Daugaard S, Lund B, Bock J, Lundvall F, Frederiksen K, Nørgaard-Pedersen B
Department of Gynaecology and Obstetrics, Herlev Hospital, Copenhagen, Denmark.
Gynecol Obstet Invest. 1992;33(3):177-82. doi: 10.1159/000294876.
Blood samples were drawn before laparotomy in 42 cases of benign, 17 cases of borderline, and 53 cases of malignant epithelial ovarian neoplasms. The concentrations of CA-125, tissue polypeptide antigen, and placental alkaline phosphatase (PLAP) were determined. No significant difference was found between the levels of CA-125 and TPA. No significant correlation was seen between tumour type and these two markers; however, both were significantly correlated to tumour malignancy and clinical stage, and CA-125 was also correlated to tumour grade. No correlation was found between PLAP and the other markers or any of the above-mentioned parameters. If at least one of two or three markers was requested to be positive, a moderate increase in the 'detection rate' of malignant tumours was found. However, the rate of positive benign samples increased to as much as 41%. Requesting at least two markers out of two or three to be positive certainly reduced the number of 'false-positive' benign tumours, but the sensitivity for malignant tumours was reduced concomitantly to levels where marker determinations would be of little use. The study demonstrated a possible, but limited role for preoperative determinations of the markers. A combination of two or three markers was not superior to single markers. The results indicate that neither of these markers will be of significant value in a screening context.
对42例良性、17例交界性和53例恶性上皮性卵巢肿瘤患者在剖腹手术前采集血样。测定CA - 125、组织多肽抗原和胎盘碱性磷酸酶（PLAP）的浓度。CA - 125和TPA水平之间未发现显著差异。肿瘤类型与这两种标志物之间无显著相关性；然而，两者均与肿瘤恶性程度和临床分期显著相关，且CA - 125也与肿瘤分级相关。未发现PLAP与其他标志物或上述任何参数之间存在相关性。如果要求两种或三种标志物中至少有一种为阳性，则恶性肿瘤的“检出率”有适度提高。然而，良性样本的阳性率高达41%。要求两种或三种标志物中至少两种为阳性确实减少了“假阳性”良性肿瘤的数量，但恶性肿瘤的敏感性也随之降低到标志物检测几乎无用的水平。该研究表明术前测定这些标志物可能有一定作用，但作用有限。两种或三种标志物联合使用并不优于单一标志物。结果表明，在筛查方面，这些标志物均无显著价值。
