在不同硫酸铵浓度下沉淀的白喉类毒素组分的剂量反应线。
The dose-response lines for diphtheria toxoid fractions precipitated at various concentrations of ammonium sulfate.
作者信息
KUROKAWA M, NAKANO T, KONDO H
出版信息
Bull World Health Organ. 1954;10(6):983-7.
Abstract
Three diphtheria toxoid preparations, fractionated at various concentrations of ammonium sulfate, having various grades of purity, and showing striking differences in immunizing potency when compared at the same Lf dose, were examined for similarity of the effective constituents in the fractions. No evidence of deviations from parallelism of the dose-response regression lines was observed; thus the statistical criteria for qualitative similarity were satisfactory met.
摘要
对三种白喉类毒素制剂进行了研究，这些制剂在不同硫酸铵浓度下分级分离，纯度各异，并且在相同Lf剂量下比较时免疫效力存在显著差异，以检验各组分中有效成分的相似性。未观察到剂量-反应回归线偏离平行性的证据；因此，定性相似性的统计标准得到了令人满意的满足。
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本文引用的文献
1
The validity and meaning of the results of biological assays.
Biometrics. 1949 Dec;5(4):273-99.
2
On the antigenicity of diphtheria toxoid. II. Preliminary report on the immunizing potency of diphtheria toxoid fractions isolated at lower ammonium sulfate concentration.
Jpn J Med. 1951 Aug;4(4):233-8. doi: 10.7883/yoken1948.4.233.
3
On the antigenicity of diphtheria toxoid. III. The immunizing potency of diphtheria toxoid fractions isolated at lower ammonium sulfate concentration.
Jpn J Med Sci Biol. 1952 Aug;5(4):239-55. doi: 10.7883/yoken1952.5.239.
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