Graham C E
Clin Orthop Relat Res. 1976 Jun(117):179-92.
This paper attempts to answer the controversial question, namely, how effective is chemonucleolysis in the treatment of discogenic back pain and sciatica? By using a type of double-blind study, a comparison has been made between 20 patients who were treated with chemonucleolysis and 20 who were treated with intra-discal hydrocortisone. The 2 year post-injection survey by an independent observer, demonstrated that chemonucleolysis produced 9 good, 3 fair, and 8 unimproved results in 20 patients. In contrast, hydrocortisone produced 3 good, 8 fair, and 8 unimproved results in 20 patients - one patient dying from unrelated causes. Although not statistically significant, the data suggest that chemonucleolysis was superior to intra-discal hydrocortisone in this series.
本文试图回答这个有争议的问题，即化学髓核溶解术治疗椎间盘源性背痛和坐骨神经痛的效果如何？通过一种双盲研究类型，对20例接受化学髓核溶解术治疗的患者和20例接受椎间盘内注射氢化可的松治疗的患者进行了比较。由独立观察者进行的注射后2年调查显示，20例接受化学髓核溶解术治疗的患者中，9例效果良好，3例效果尚可，8例无改善。相比之下，20例接受氢化可的松治疗的患者中，3例效果良好，8例效果尚可，8例无改善——1例患者死于无关原因。尽管无统计学意义，但数据表明在该系列中化学髓核溶解术优于椎间盘内注射氢化可的松。
