Shenker Y, Meranda D, Clinkingbeard C, Lawrence D, Koch D
Department of Medicine, University of Wisconsin-Madison.
J Lab Clin Med. 1992 Aug;120(2):297-304.
The effect of atrial natriuretic hormone (ANH) on metoclopramide-induced stimulation of aldosterone was studied in eight healthy young men after 3 days of controlled diet (150 mEq sodium, 100 mEq potassium). Baseline values were obtained after subjects had remained sitting for 1 hour. Subjects then received 2-hour infusions of placebo, dopamine (2 micrograms/kg/min), ANH (0.6 pmol/kg/min), and ANH plus dopamine. One hour after the beginning of each infusion, a 10 mg intravenous bolus of metoclopramide was given. Prolactin levels increased 10-fold after metoclopramide with placebo infusion, and about 50% of this stimulation was abolished by preinfusion with dopamine. ANH preinfusion did not suppress prolactin release. Urinary sodium excretion increased prominently during dopamine infusion. ANH at this dose had no effect on natriuresis. The dopamine dose given had almost no effect on metoclopramide-induced aldosterone secretion, whereas ANH infusions, which resulted in approximate doubling of plasma ANH levels, suppressed aldosterone. This study supports a role of ANH in aldosterone regulation, even at nonnatriuretic doses, and suggests that ANH is acting not only through the renin-angiotensin system but under certain conditions has significant physiologic action directly on glomerulosa cells.
在8名健康年轻男性经过3天控制饮食（150毫当量钠，100毫当量钾）后，研究了心房利钠激素（ANH）对甲氧氯普胺诱导的醛固酮刺激作用的影响。在受试者静坐1小时后获取基线值。然后受试者接受安慰剂、多巴胺（2微克/千克/分钟）、ANH（0.6皮摩尔/千克/分钟）以及ANH加多巴胺的2小时输注。在每次输注开始1小时后，静脉推注10毫克甲氧氯普胺。在输注安慰剂时，甲氧氯普胺使催乳素水平升高了10倍，而预先输注多巴胺可消除约50%的这种刺激作用。预先输注ANH并未抑制催乳素释放。在输注多巴胺期间尿钠排泄显著增加。此剂量的ANH对利钠作用无影响。所给予的多巴胺剂量对甲氧氯普胺诱导的醛固酮分泌几乎无影响，而导致血浆ANH水平约翻倍的ANH输注则抑制了醛固酮。本研究支持ANH在醛固酮调节中的作用，即使在非利钠剂量下也是如此，并表明ANH不仅通过肾素 - 血管紧张素系统起作用，而且在某些情况下对球状带细胞具有直接的重要生理作用。
