Mark J, Dahlenfors R, Stenman G, Bende M, Melén I
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
Anticancer Res. 1992 Jul-Aug;12(4):1195-8.
The cytogenetical findings in two cases of cultured salivary polymorphous low-grade adenocarcinoma (PLGA) are reported. The first PLGA was a carcinoma ex pleomorphic adenoma of the parotid gland. This had a pseudodiploid stemline characterized by extensive and complicated structural rearrangements. The chromosomal findings showed many similarities to those in the only previously studied case of PLGA (also a carcinoma ex pleomorphic adenoma of the parotid). The results in both could fit with abnormalities superimposed on those typical of mixed tumors. The second PLGA reported derived from a minor salivary gland. It showed a completely different picture, distinguished by a hypodiploid, almost exclusively numerical, variation and the occurrence of a stemline characterized by only monosomy 22. Etiological differences were proposed as one possible explanation for the cytogenetical differences between the two types of PLGA.
报告了两例培养的涎腺多形性低度腺癌（PLGA）的细胞遗传学研究结果。第一例PLGA是腮腺多形性腺瘤恶变。其具有假二倍体主干系，特征为广泛且复杂的结构重排。染色体研究结果与之前唯一一例PLGA（也是腮腺多形性腺瘤恶变）的研究结果有许多相似之处。两者的结果均符合叠加于混合瘤典型异常之上的异常情况。报告的第二例PLGA起源于小涎腺。其呈现出完全不同的情况，特征为亚二倍体，几乎完全是数目变异，且出现了仅以22号染色体单体为特征的主干系。病因学差异被认为是两种类型PLGA细胞遗传学差异的一种可能解释。
