Cruz-Sanchez F F, Rossi M L, Cardozo A, Picardo A, Tolosa E
Neurological Tissue Bank, Hospital Clinico y Provincial, University of Barcelona, Spain.
J Neurol Sci. 1992 Jul;110(1-2):228-31. doi: 10.1016/0022-510x(92)90032-g.
The grumose degeneration observed in the dentate nuclei of 7 cases of progressive supranuclear palsy (PSP) was studied with a panel of antibodies which included 2 neurofilaments, Tau and ubiquitin. Dentate nucleus neurons were negative with all antibodies except ubiquitin which showed a slightly positive homogeneous pattern of staining. The amorphous material surrounding swollen or normal neurons was strongly positive for neurofilament and subunits and numerous torpedoes were observed in the granular layer of the cerebellar cortex. Our results confirm that grumose degeneration consists in degeneration of terminal axons of Purkinje cells in the dentate nucleus. The positivity of dentate nucleus neurons for ubiquitin may support the concept of synaptic dysfunction between Purkinje cells and dentate nucleus neurons.
我们使用一组抗体，包括2种神经丝、Tau和泛素，对7例进行性核上性麻痹（PSP）患者齿状核中观察到的颗粒样变性进行了研究。除泛素呈轻度均匀阳性染色外，齿状核神经元对所有抗体均呈阴性。肿胀或正常神经元周围的无定形物质对神经丝及其亚基呈强阳性，并且在小脑皮质颗粒层中观察到大量鱼雷样结构。我们的结果证实，颗粒样变性在于齿状核中浦肯野细胞终末轴突的变性。齿状核神经元对泛素呈阳性可能支持浦肯野细胞与齿状核神经元之间突触功能障碍的概念。
