Inoue M, Hasobe N, Hirata Y, Okubo T
Department of Microbiology, Kitasato University, School of Medicine.
Nihon Rinsho. 1992 May;50(5):1026-35.
Most methicillin-resistant Staphylococcus aureus (MRSA) isolates are multiply resistant to various antimicrobial agents. Therefore, MRSA strains have become a serious problem in the clinical setting. However, it should be noted that the frequency of isolation of strains resistant to aminoglycoside and minocycline was not significantly different between low- and high-MRSA isolates and the isolation frequency of high-MRSA strains, less susceptible to not only beta-lactam antibiotics but also to macrolide antibiotics and quinolones, was significantly higher than the corresponding values for low-MRSA strains. These results suggest that high-MRSA strains were selected by antimicrobial agents for the treatment with the patients.
大多数耐甲氧西林金黄色葡萄球菌（MRSA）分离株对多种抗菌药物具有多重耐药性。因此，MRSA菌株已成为临床环境中的一个严重问题。然而，应当指出的是，耐氨基糖苷类和米诺环素菌株的分离频率在低MRSA和高MRSA分离株之间并无显著差异，并且高MRSA菌株的分离频率显著高于低MRSA菌株，高MRSA菌株不仅对β-内酰胺类抗生素不敏感，而且对大环内酯类抗生素和喹诺酮类也不敏感。这些结果表明，高MRSA菌株是由用于治疗患者的抗菌药物选择出来的。
