促甲状腺激素释放激素的失活
Inactivation of the thyrotropin releasing hormone.
作者信息
Bauer K, Schulz M
机构信息
Max-Planck-Institut für experimentelle Endokrinologie, Hannover, Germany.
出版信息
Acta Med Austriaca. 1992;19 Suppl 1:79-82.
PMID:1325726
Abstract
Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme. For these enzymes, the high degree of substrate specificity, the tissue specific hormonal regulation, the unusual tissue and the heterogenous cellular distribution strongly suggests that they serve very specialized functions for the transmission of TRH signals at specific target sites.
摘要
促甲状腺激素释放激素（TRH；焦谷氨酸-组氨酸-脯氨酸-酰胺）通过一种分布不均一的胞外酶和一种TRH降解血清酶在焦谷氨酸-组氨酸键处迅速水解。对于这些酶而言，高度的底物特异性、组织特异性激素调节、特殊的组织以及不均一的细胞分布强烈表明，它们在特定靶位点传递TRH信号时发挥着非常特殊的功能。
Zotero 插件