Van Iwaarden J F, Shimizu H, Van Golde P H, Voelker D R, Van Golde L M
Laboratory of Veterinary Biochemistry, University of Utrecht, The Netherlands.
Biochem J. 1992 Aug 15;286 ( Pt 1)(Pt 1):5-8. doi: 10.1042/bj2860005.
Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.