Mira M L, Silva M M, Queirós M J, Manso C
Instituto de Química Fisiológica. Faculdade de Medicina de Lisboa.
Rev Port Cardiol. 1992 May;11(5):425-30.
Angiotensin converting enzyme inhibitors are utilized in the treatment of essential hypertension and of chronic cardiac failure. They are also employed in the treatment of the myocardial lesion of ischemia-reperfusion, which involves oxygen free radicals. In the present study we investigated the possibility of three angiotensin converting enzyme inhibitors (captopril, enalapril, lisinopril) to act as hydroxyl radical scavengers. The rate constants for reactions of those compounds with .OH were determined using the deoxyribose method. All there compounds proved to be good scavengers of .OH with rate constants of about 10(10)M-1s-1 and are iron chelators specially enalapril. The fact that captopril possesses a thiol group does not confer an higher antioxidative capacity. These results suggest that scavenging of oxygen free radicals may be a possible mechanism contributing to the therapeutic effect of angiotensin converting enzyme inhibitors.
血管紧张素转换酶抑制剂用于治疗原发性高血压和慢性心力衰竭。它们也被用于治疗涉及氧自由基的缺血再灌注心肌损伤。在本研究中，我们研究了三种血管紧张素转换酶抑制剂（卡托普利、依那普利、赖诺普利）作为羟自由基清除剂的可能性。使用脱氧核糖法测定了这些化合物与·OH反应的速率常数。所有这三种化合物都被证明是良好的·OH清除剂，速率常数约为10(10)M-1s-1，并且都是铁螯合剂，特别是依那普利。卡托普利含有巯基这一事实并未赋予其更高的抗氧化能力。这些结果表明，清除氧自由基可能是血管紧张素转换酶抑制剂发挥治疗作用的一种可能机制。
