Grafnetterová J, Blahosová A, Beradilová M
Physiol Bohemoslov. 1976;25(3):235-40.
After 12 days of intramuscular administration of 6-azauridine (500 mg/kg b.w.) rats displayed a significant decrease in plasma calcium, inorganic phosphorus, and total hydroxyproline levels and alkaline and acid phosphatase activity. The biological method employed revealed no changes in calcitonin activity. 6-Azauridine reduced the citric acid concentration in the kidneys, liver, heart and bones. Alkaline phosphatase activity in the kidneys, heart and liver was unaffected. The results indicate that 6-azauridine inhibits calcium resorption from the bones and interferes with collagen synthesis. It cannot be ruled out that the described changes are elicited by the antimetabolic effect of this cytostatic drug.
连续12天给大鼠肌肉注射6-氮尿苷（500毫克/千克体重）后，大鼠血浆钙、无机磷、总羟脯氨酸水平以及碱性和酸性磷酸酶活性显著降低。所采用的生物学方法显示降钙素活性无变化。6-氮尿苷降低了肾脏、肝脏、心脏和骨骼中的柠檬酸浓度。肾脏、心脏和肝脏中的碱性磷酸酶活性未受影响。结果表明，6-氮尿苷抑制骨钙重吸收并干扰胶原蛋白合成。不能排除所述变化是由这种细胞抑制药物的抗代谢作用引起的。
