含有磺酰胺、硫酸盐、甲基膦酸酯和羧甲基基团的肌醇1,4,5-三磷酸类似物的合成。
Synthesis of analogues of myo-inositol 1,4,5-trisphosphate that contain sulfonamide, sulfate, methylphosphonate, and carboxymethyl groups.
作者信息
Westerduin P, Willems H A, van Boeckel C A
机构信息
Akzo Pharma, Organon Scientific Development Group, Oss, Netherlands.
出版信息
Carbohydr Res. 1992 Oct 9;234:131-40. doi: 10.1016/0008-6215(92)85044-z.
PMID:1334798
Abstract
The syntheses are described of four isosteric racemic myo-inositol 1,4,5-trisphosphate (1) analogues with the phosphate groups replaced by sulfonamide (2), sulfate (3), methylphosphonate (4), and carboxymethyl (5). None of these compounds had any affinity for the IP3 receptor or induced platelet aggregation.
摘要
描述了四种等排体的外消旋肌醇1,4,5 -三磷酸酯（1）类似物的合成，其中磷酸基团被磺酰胺（2）、硫酸酯（3）、甲基膦酸酯（4）和羧甲基（5）取代。这些化合物均对IP3受体没有任何亲和力，也不会诱导血小板聚集。
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