小鼠α2C2肾上腺素能受体亚型基因的分子克隆与特性分析
Molecular cloning and characterization of a mouse alpha 2C2 adrenoceptor subtype gene.
作者信息
Chen W M, Chang A C, Shie B J, Chang Y H, Chang N C
机构信息
Institute of Microbiology and Immunology, Neuroscience and Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, ROC.
出版信息
Biochim Biophys Acta. 1992 Dec 29;1171(2):219-23. doi: 10.1016/0167-4781(92)90126-k.
A clone MA2C2 encoding the murine homologue of adrenoceptor alpha 2C2 was isolated from a mouse genomic library using a subtype specific probe. The nucleotide and the deduced amino acid sequences derived from an ApaI fragment (2 kb) of the clone reveal a single open reading frame encoding a putative receptor protein of 455 amino acids. The 5' untranslated region (0.5 kb) sequenced is characterized by high GC content and CpG island count.
使用亚型特异性探针从小鼠基因组文库中分离出一个编码肾上腺素能α2C2受体小鼠同源物的克隆MA2C2。从该克隆的一个ApaI片段（2 kb）获得的核苷酸和推导的氨基酸序列显示出一个单一的开放阅读框，编码一个由455个氨基酸组成的假定受体蛋白。测序的5'非翻译区（0.5 kb）的特征是高GC含量和CpG岛计数。
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