有丝分裂中新生DNA的分布。

The distribution of newly synthesized DNA in mitotic division.

作者信息

MAZIA D, PLAUT W

出版信息

J Biophys Biochem Cytol. 1956 Sep 25;2(5):573-88. doi: 10.1083/jcb.2.5.573.

DOI:10.1083/jcb.2.5.573

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2223985/

Abstract

The chromosomes of Crepis capillaris were labelled with thymidine-2-C(14) in their DNA fraction. Quantitative analysis of the distribution of newly synthesized DNA in postmetaphase stages of the division following the period of label incorporation led to the conclusion that the new DNA is not necessarily equally distributed by the mitotic process and that, therefore, chromosome duplication does not involve the equal partition of parental DNA. The implications of these findings with respect to DNA duplication are discussed. An attempt is made to translate the pattern of new DNA distribution into a probable number of units of synthesis per chromosome.

摘要

用胸腺嘧啶 - 2 - C（14）标记了毛连菜（Crepis capillaris）染色体的DNA部分。在掺入标记后的分裂后期阶段，对新合成DNA的分布进行定量分析，得出的结论是，新DNA不一定通过有丝分裂过程均匀分布，因此，染色体复制并不涉及亲代DNA的均等分配。讨论了这些发现对DNA复制的意义。试图将新DNA分布模式转化为每条染色体可能的合成单位数量。

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