内侧杏仁核电刺激对垂体切除大鼠肾上腺皮质对促肾上腺皮质激素敏感性的影响。

Influence of the electrical stimulation of the medial amygdala on adrenocortical sensitivity to adrenocorticotrophin in hypophysectomized rats.

作者信息

Saito H, Sato T, Kaba H, Okutani F, Yu G Z, Seto K, Kimura F, Kawakami M, Roberts S

机构信息

Department of Physiology, Kochi Medical School, Nankoku, Japan.

出版信息

Exp Clin Endocrinol. 1992;100(3):145-7. doi: 10.1055/s-0029-1211195.

DOI:10.1055/s-0029-1211195

PMID:1339032

Abstract

The effects of electrical stimulation of medial amygdala on the adrenocortical sensitivity to adrenocorticotrophin (ACTH) were investigated in hypophysectomized rats. The intravenous injection of ACTH increased the rates of 14C transfer from 14C-l-acetate into corticosterone and cortisol in the adrenal slices of hypophysectomized rats. The electrical stimulation of the medial amygdala produced a further increase in the rates of 14C transfer from 14C-l-acetate into corticosterone and cortisol. From these results, it might be suggested that the medial amygdala was capable of enhancing the adrenocortical steroidogenesis in response to ACTH.

摘要

在垂体切除的大鼠中，研究了内侧杏仁核电刺激对肾上腺皮质对促肾上腺皮质激素（ACTH）敏感性的影响。静脉注射ACTH可提高垂体切除大鼠肾上腺切片中14C从14C-1-醋酸盐向皮质酮和皮质醇的转移率。内侧杏仁核的电刺激使14C从14C-1-醋酸盐向皮质酮和皮质醇的转移率进一步提高。从这些结果可以推测，内侧杏仁核能够增强肾上腺皮质对ACTH的类固醇生成反应。