Costello R, Duffaud F
Unité INSERM U 119, Marseille, France.
Eur J Med. 1992 May;1(2):119-21.
Interleukin-7 (IL-7) is a cytokine initially described as a growth factor for B cell progenitors. IL-7 also induces T cell proliferation and has pleiotropic effects. IL-7 enhances T-lymphocyte cytotoxicity, stimulates anti-tumoural properties of monocytes/macrophages, and induces tumour rejection in mice. It could thus be of interest in immunotherapy and may play a role in the generation of lymphoid neoplasia because leukaemic cells of B and T lineage express functional IL-7 receptors. Finally, IL-7 is, as IL-2, a cytokine of pivotal importance in the immune system, and so could be involved in abnormal immune response such as autoimmunity.
白细胞介素-7（IL-7）是一种细胞因子，最初被描述为B细胞祖细胞的生长因子。IL-7还可诱导T细胞增殖，并具有多效性作用。IL-7可增强T淋巴细胞的细胞毒性，刺激单核细胞/巨噬细胞的抗肿瘤特性，并在小鼠中诱导肿瘤排斥反应。因此，它在免疫治疗中可能具有重要意义，并且可能在淋巴样肿瘤的发生中起作用，因为B和T谱系的白血病细胞表达功能性IL-7受体。最后，与IL-2一样，IL-7是免疫系统中至关重要的细胞因子，因此可能参与自身免疫等异常免疫反应。
