与二氨基二苯氧基烷类似的物质对曼氏血吸虫的作用。
The action of substances analogous to diaminodiphenoxyalkanes against Schistosoma mansoni.
作者信息
GORVIN J H, RAISON C G, SOLOMON W, STANDEN O D, WALLS L P
出版信息
Br J Pharmacol Chemother. 1957 Sep;12(3):329-35. doi: 10.1111/j.1476-5381.1957.tb00143.x.
Abstract
The effects on activity against Schistosoma mansoni of further modifications of the diaminodiphenoxyalkanes are reported. Replacement of the amino-group by any of a large number of other groups destroys activity. Activity is retained in the presence of certain substituted (hydroxyalkyl, carboxyalkyl) amino-groups and in some of their aldehyde-bisulphite derivatives. Many variations of the central chain lead to compounds of reduced activity, the outstanding exceptions being a number of but-2-ene derivatives, which retain full activity.
摘要
本文报道了二氨基二苯氧基烷烃进一步修饰后对曼氏血吸虫活性的影响。用大量其他基团中的任何一个取代氨基都会破坏活性。在某些取代的（羟烷基、羧烷基）氨基存在下及其一些醛亚硫酸氢盐衍生物中，活性得以保留。中心链的许多变化会导致活性降低的化合物，突出的例外是一些丁 - 2 - 烯衍生物，它们保留了全部活性。
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本文引用的文献
1
The schistosomicidal activity of symmetrical diaminodiphenoxyalkanes.对称二氨基二苯氧基烷烃的杀血吸虫活性。
Br J Pharmacol Chemother. 1955 Jun;10(2):191-9. doi: 10.1111/j.1476-5381.1955.tb00082.x.
2
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3
The activity of p-aminophenoxyalkane derivatives against Schistosoma mansoni.对氨基苯氧基烷衍生物对曼氏血吸虫的活性。
Br J Pharmacol Chemother. 1956 Dec;11(4):367-74. doi: 10.1111/j.1476-5381.1956.tb00004.x.
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