Aterman K
J Cancer Res Clin Oncol. 1992;118(2):87-115. doi: 10.1007/BF01187498.
The current status of the much-debated question of the still-hypothetical stem cells of the liver is reviewed, with an emphasis on their role in hepatocarcinogenesis. The widely held view of the primacy of the hepatocyte, notably of the mononuclear diploid type, in this process--the "hepatocytic theory"--has been compared with variants of the "stem cell hypothesis" based on the "non-parenchymal epithelial cells" of the liver--the "oval" or biliary ductular cells, the "nondescript periductular" cells and the "primitive" bipotential epithelial cells. An attempt has been made to concentrate mainly on the more recent publications, in an effort to balance the conflicting opinions expressed by comparing results obtained by the newer procedures currently in use. Despite some interesting and relevant findings it appears that the evidence in favour of the stem-cell hypothesis is still circumstantial and that the hepatocytic theory has not been invalidated. Presumably the question of the hepatic stem cells will be answered when the riddle of hepatocarcinogenesis has been solved.
本文综述了关于肝脏中仍属假设的干细胞这一备受争议问题的现状，重点探讨了它们在肝癌发生中的作用。在这一过程中，肝细胞尤其是单核二倍体类型的肝细胞占主导地位的广泛观点——“肝细胞理论”——已与基于肝脏“非实质上皮细胞”的“干细胞假说”变体进行了比较，这些非实质上皮细胞包括“卵圆”细胞或胆小管细胞、“难以描述的导管周围”细胞以及“原始”双能上皮细胞。本文主要集中于较新的出版物，试图通过比较目前使用的新方法所获得的结果来平衡相互矛盾的观点。尽管有一些有趣且相关的发现，但支持干细胞假说的证据似乎仍然是间接的，肝细胞理论也并未被推翻。推测当肝癌发生之谜被解开时，肝脏干细胞的问题也将得到解答。
