Wong K K, Tzeng S F
Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China.
Artery. 1992;19(1):1-13.
The present study examined contractile responses to norepinephrine in isolated aortae from 4-, 8-, and 12-week duration of streptozocin-induced diabetic rats. The pD2 value and the maximum contractile responses were significantly increased in 8-week and 12-week diabetic aortae, respectively, compared to the age-matched control aortae. Moreover, the bethanechol-induced relaxation of 12-week diabetic aortae preconstricted with norepinephrine was also significantly different from the age-matched control aortae. On the other hand, the KCl-, phenylephrine-induced contraction in 4-, 8-, and 12-week diabetic and age-matched control aortae were similar. Presumably the duration of diabetes altered the sensitivity and responsiveness of aortae to norepinephrine. The possibility of the enhanced norepinephrine response in diabetic aortae was discussed.
本研究检测了链脲佐菌素诱导的糖尿病大鼠在4周、8周和12周时分离的主动脉对去甲肾上腺素的收缩反应。与年龄匹配的对照主动脉相比，8周和12周糖尿病主动脉的pD2值和最大收缩反应分别显著增加。此外，用去甲肾上腺素预收缩的12周糖尿病主动脉对氨甲酰甲胆碱诱导的舒张也与年龄匹配的对照主动脉有显著差异。另一方面，4周、8周和12周糖尿病及年龄匹配的对照主动脉对氯化钾、去氧肾上腺素诱导的收缩相似。推测糖尿病病程改变了主动脉对去甲肾上腺素的敏感性和反应性。文中讨论了糖尿病主动脉中去甲肾上腺素反应增强的可能性。
