Bidzseranova A, Gueron J, Tóth G, Penke B, Telegdy G
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Eur J Pharmacol. 1992 Feb 18;211(3):411-4. doi: 10.1016/0014-2999(92)90399-o.
In previous experiments, it was observed that rat atrial natriuretic peptide-(1-28) (ANP-(1-28)) participated in fear-induced learning and memory processes via dopaminergic and cholinergic mediation. Since cage-climbing behavior is described as a simple test for studying dopaminergic activity in the central nervous system, a systemic study was carried out with ANP-(1-28) in order to confirm or to exclude the possible involvement of dopamine in the ANP-induced action in the brain. The present study demonstrate that ANP-(1-28) facilitated cage-climbing behavior in mice in a dose-dependent manner. When combined with apomorphine, the peptide potentiated the effect of the dopamine agonist. The effect of ANP-(1-28) in combination with apomorphine could be antagonized by a selected dose of haloperidol. These data suggest that ANP might be regarded as a dopamine agonist-modulating agent and that a dopaminergic mechanism is a possible mode of action of ANP in the fear-induced learning studied earlier.
在先前的实验中，观察到大鼠心房利钠肽-（1-28）（ANP-（1-28））通过多巴胺能和胆碱能介导参与恐惧诱导的学习和记忆过程。由于爬笼行为被描述为研究中枢神经系统中多巴胺能活性的一种简单测试，因此对ANP-（1-28）进行了一项系统研究，以确认或排除多巴胺可能参与ANP在脑中诱导的作用。本研究表明，ANP-（1-28）以剂量依赖的方式促进小鼠的爬笼行为。当与阿扑吗啡联合使用时，该肽增强了多巴胺激动剂的作用。ANP-（1-28）与阿扑吗啡联合使用的效果可被选定剂量的氟哌啶醇拮抗。这些数据表明，ANP可能被视为一种多巴胺激动剂调节剂，并且多巴胺能机制可能是ANP在早期研究的恐惧诱导学习中的一种作用方式。
