Friedman E, Shopsin B, Gershon S
Res Commun Chem Pathol Pharmacol. 1976 Sep;15(1):191-4.
The effect of p-chlorophenylalanine-treatment in rats receiving chronic treatment with tranylcypromine on brain serotonin and 5-hydroxyindoleacetic acid levels was examined. This treatment schedule was similar to that followed in depressed patients undergoing treatment with the monoamine oxidase inhibitor. PCPA completely obviated the elevation in serotonin and further reduced 5-HIAA levels of animals treated chronically with tranylcypromine. These effects correlated with PCPA-induced reversal in the clinical improvement achieved by tranylcypromine. In in vitro studies, tranylcypromine was found to inhibit 5-HT uptake into synaptosomes with a minimal action on the spontaneous release of the amine.
研究了对接受反苯环丙胺长期治疗的大鼠进行对氯苯丙氨酸处理对其脑血清素和5-羟基吲哚乙酸水平的影响。这种治疗方案类似于接受单胺氧化酶抑制剂治疗的抑郁症患者所采用的方案。对氯苯丙氨酸完全消除了血清素的升高，并进一步降低了接受反苯环丙胺长期治疗的动物的5-羟色胺酸水平。这些效应与对氯苯丙氨酸诱导的反苯环丙胺所实现的临床改善的逆转相关。在体外研究中，发现反苯环丙胺抑制5-羟色胺摄取到突触体中，对胺的自发释放作用极小。
