Detection of serum IgM antibodies to glomerular basement membrane in two cases of nephropathia epidemica.
作者信息
Billheden J, Settergren B, Stegmayr B, Juto P
机构信息
Department of Infectious Diseases, University Hospital, Umeå, Sweden.
出版信息
J Intern Med. 1992 Jul;232(1):91-3. doi: 10.1111/j.1365-2796.1992.tb00556.x.
Abstract
We report two serologically verified cases of nephropathia epidemica (NE) who developed high serum levels of non-Goodpasture IgM antibodies against glomerular basement membrane (anti GBM) in the acute phase of the disease. Moreover, in one of the patients a renal biopsy showed granular deposits of complement factor 3 along the glomerular capillary walls. The possible pathogenic significance of these findings is discussed.
摘要
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