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21号染色体嵌合型和三体型唐氏综合征患者心理发育的比较。

Comparison of mental development in individuals with mosaic and trisomy 21 Down's syndrome.

作者信息

Fishler K, Koch R, Donnell G N

出版信息

Pediatrics. 1976 Nov;58(5):744-8.

PMID:135957
Abstract

During the past 15 years about 350 children with Down's syndrome have been seen at Children's Hospital of Los Angeles for psychological evaluation along with medical visits and other laboratory tests. Among this group there were 25 mosaic Down's syndrome children identified by chromosome analyses. They were matched for sex and chronological age with 25 trisomy 21 subjects and compared on psychological tests. The mosaic group demonstrated significantly higher intellectual potential, better verbal facility, and less visual perceptual difficulties than the trisomy 21 group. Their behavioral adjustment and personality characterisitcs were similar to those observed in other types of Down's syndrome. Since present psychological assessment techniques do not permit reaching valid conclusions about the ultimate intellectual status in very young infants with Down's syndrome, physicians and other professionals need to be careful when recommending early placement outside the home based merely upon the diagnosis.

摘要

在过去15年里,约350名患有唐氏综合征的儿童前往洛杉矶儿童医院进行心理评估,同时接受医疗检查和其他实验室检测。在这一组中,通过染色体分析鉴定出25名嵌合型唐氏综合征儿童。他们在性别和实足年龄上与25名21三体综合征患者相匹配,并在心理测试中进行比较。嵌合型组在智力潜能、语言能力方面明显更高,视觉感知困难比21三体综合征组更少。他们的行为调适和性格特征与其他类型唐氏综合征中观察到的相似。由于目前的心理评估技术无法对患有唐氏综合征的非常年幼婴儿的最终智力状况得出有效结论,医生和其他专业人员在仅根据诊断就建议早期家庭外安置时需要谨慎。

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