Effect of d-6-methyl-8-ergoline-i-ylacetamide (Deprenon) on the FSH content of the pituitary in castrated female rats.

The authors studied the effect of Deprenon (D-6-methyl-8-ergoline-I-acetylamide tartrate) on the FSH content of the adenohypophysis of female rats which had been castrated 3 and 6 weeks previously. The FSH content, determined by the method of Johnson and Naqui (1970), is expressed at the mean weights of the recipients' ovaries compared with a group given only 30 I.U. HCG. Within 30 min after administration, a single peroral dose of 0.5 mg Deprenon/kg produced a drop in the pituitary FSH content. This was not very pronounced 3 weeks after castration, but was highly significant 6 weeks after castration, when the amount of FSH in the control animals' pituitaries rose.