Musk M, Anderson H, Oreopoulos D, Leiter L, Bargman J, Pettit J, Jones M
Department of Nutritional Sciences, University of Toronto, Canada.
Adv Perit Dial. 1992;8:153-6.
The use of amino acid (AA) dialysate in CAPD patients may have theoretical disadvantages, since protein ingestion is known to suppress food intake in humans disproportionately to its energy value. Therefore we measured subjective appetite and food intake of CAPD patients in a cross-over study of 16 subjects (age 22-75 years, BMI 19-31, > 3 months on CAPD, non-diabetic and not protein malnourished). They received, in random order, either 4 weeks of dextrose only (their usual treatment), or one AA (1%) exchange replacing the first dextrose exchange each day. Subjective measurements of food intake (3 day food record) and quantitative measurements of lunch time food intake were obtained during a morning dextrose exchange after 28 days of each regimen. Except for a reduction in feelings of fullness during the AA treatment, there were no effects on feelings of hunger/satiety, food appeal, lunch-time food intake, or on 3-day food intake. We conclude that the use of a daily AA (1%) dialysate for 4 weeks does not affect subjective appetite or food intake of CAPD patients. There may even be a beneficial effect as the feeling of fullness decreased with the AA treatment.
在持续性非卧床腹膜透析（CAPD）患者中使用氨基酸（AA）透析液可能存在理论上的弊端，因为已知蛋白质摄入对人体食物摄入量的抑制作用与其能量值不成比例。因此，我们在一项针对16名受试者（年龄22 - 75岁，体重指数19 - 31，进行CAPD治疗超过3个月，非糖尿病且无蛋白质营养不良）的交叉研究中，测量了CAPD患者的主观食欲和食物摄入量。他们随机接受以下两种治疗，每种治疗为期4周：仅使用葡萄糖（他们的常规治疗），或每天进行一次AA（1%）交换，替代第一次葡萄糖交换。在每种治疗方案进行28天后，于上午葡萄糖交换期间，获取食物摄入量的主观测量值（3天食物记录）和午餐时间食物摄入量的定量测量值。除了在AA治疗期间饱腹感有所降低外，对饥饿/饱腹感、食物吸引力、午餐时间食物摄入量或3天食物摄入量均无影响。我们得出结论，每天使用AA（1%）透析液4周不会影响CAPD患者的主观食欲或食物摄入量。随着AA治疗，饱腹感降低，甚至可能存在有益效果。
