WRIGHT R R
Calif Med. 1959 Jan;90(1):14-6.
Interstitial pneumonias present a pulmonary inflammatory reaction pattern that is common to a wide variety of noxious agents and disease processes. These include viruses, Rickettsiae, hypersensitivity reactions, the "collagen disease," x-irradiation, uremia, certain chemicals, early histoplasmosis, toxoplasmosis and possibly unknown substances and diseases. Interstitial pneumonia is characterized histologically by interalveolar exudate, hyaline membranes, epithelialization of alveolar walls and lack of polymorphonuclear response. Histologic features that aid in differentiating among cases of varying etiology are few. It is postulated that the basic pathogenic mechanism of the interstitial inflammatory reaction is primary damage to pulmonary capillary endothelium that brings about increased capillary permeability.
间质性肺炎呈现出一种肺部炎症反应模式，这种模式在多种有害因子和疾病过程中很常见。这些包括病毒、立克次氏体、超敏反应、“胶原病”、X线照射、尿毒症、某些化学物质、早期组织胞浆菌病、弓形虫病以及可能的未知物质和疾病。间质性肺炎在组织学上的特征是肺泡内渗出、透明膜形成、肺泡壁上皮化以及缺乏多形核反应。有助于区分不同病因病例的组织学特征很少。据推测，间质性炎症反应的基本致病机制是肺毛细血管内皮的原发性损伤，这导致毛细血管通透性增加。
