大鼠体内硅的代谢及其与人工硅质结石形成的关系。

The metabolism of silicon in the rat and its relation to the formation of artificial siliceous calculi.

作者信息

KELLER R F, LOVELACE S A

出版信息

J Exp Med. 1959 Jun 1;109(6):601-14. doi: 10.1084/jem.109.6.601.

DOI:10.1084/jem.109.6.601

PMID:13654631

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2136979/

Abstract

The urinary excretion of silicon in the rat was found to be enhanced beyond normal levels by the administration of various chemical forms of silicon. The excretion was enhanced to a much greater degree by the administration of ethyl silicate than by magnesium trisilicate, sodium metasilicate, or water glass. The tolerance level of rats to sustained daily doses of ethyl silicate fed via stomach tube was approximately 15 to 30 mg. of silicon per rat per day. Urinary silicon excretion was found to be a straight line function of the concentration of ethyl silicate administered, via stomach tube, with approximately 18 per cent of the administered silicon appearing in the urine at all levels tested. Using sustained dietary additions of ethyl silicate as a means of enhancing urine silicon levels, artificial siliceous urinary calculi were consistently produced on zinc pellets implanted in the bladders of rats.

摘要

研究发现，给大鼠施用各种化学形式的硅后，其尿中硅的排泄量会超过正常水平。与三硅酸镁、偏硅酸钠或水玻璃相比，施用硅酸乙酯后，排泄量的增加幅度要大得多。通过胃管给大鼠持续每日喂食硅酸乙酯，其耐受水平约为每只大鼠每天15至30毫克硅。研究发现，通过胃管施用的硅酸乙酯浓度与尿中硅排泄量呈直线关系，在所有测试水平下，约18%施用的硅会出现在尿液中。使用持续在饮食中添加硅酸乙酯的方法来提高尿中硅水平，在植入大鼠膀胱的锌丸上会持续形成人工硅质尿路结石。