某些强心苷和苷元在豚鼠体内的作用持续时间。
The duration of action of some cardiac glycosides and aglycones in the guinea-pig.
作者信息
RAND M, STAFFORD A
出版信息
Br J Pharmacol Chemother. 1959 Jun;14(2):174-8. doi: 10.1111/j.1476-5381.1959.tb01379.x.
A method is described for determining the duration of action of cardiac glycosides and aglycones in the guinea-pig. It is based on their property of potentiating the cardiac response to adenosine. The method is particularly suitable for those drugs with a short duration of action, whereas previous methods are more suitable for those drugs with longer durations of action. The duration of action of one-fifth of the lethal dose has been found for: digoxigenin, lanatoside C, ouabain, digitoxigenin-3-one, digitoxin, 3-acetyldigitoxigenin, digoxin, digitoxigenin, lanatoside A; these drugs are arranged in order of increasing duration of action. The possible relationship between the elimination of these drugs and their duration of action can provide an estimate of their rates of elimination.
本文描述了一种测定豚鼠体内强心苷和苷元作用持续时间的方法。该方法基于它们增强心脏对腺苷反应的特性。此方法特别适用于作用持续时间短的药物，而先前的方法更适用于作用持续时间长的药物。已测定了以下药物五分之一致死剂量的作用持续时间：洋地黄毒苷元、毛花苷C、哇巴因、洋地黄毒苷元-3-酮、地高辛、3-乙酰洋地黄毒苷元、地高辛、洋地黄毒苷、毛花苷A；这些药物按作用持续时间递增顺序排列。这些药物的消除与其作用持续时间之间的可能关系可提供其消除速率的估计值。
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