温度与电诱导心室颤动时离子浓度变化之间的关系。
The relation between temperature and changes in ion concentration on ventricular fibrillation induced electrically.
作者信息
MILTON A S
出版信息
Br J Pharmacol Chemother. 1959 Jun;14(2):183-5. doi: 10.1111/j.1476-5381.1959.tb01381.x.
Further observations have been made on ventricular fibrillation induced by electrical stimulation in the isolated rabbit heart, in extension of the finding that fibrillation was arrested by cooling from 37 degrees to 32 degrees . The observations now made suggest that at 37 degrees the isolated rabbit heart perfused with Locke solution is on the edge of anoxia, but that at 32 degrees the oxygen supply is adequate. At the lower temperature the proportion of hearts fibrillating at any given potassium concentration was reduced, so, although the proportion of hearts fibrillating rose as the potassium concentration fell, even when the latter was one-quarter of the normal the proportion was not higher than 67%. The relation of the concentration of calcium ions to the proportion of hearts fibrillating changed from biphasic at 37 degrees to almost rectilinear at 32 degrees , the proportion increasing as the concentration of calcium ions rose. It was confirmed that a reduction in sodium concentration also raises the proportion of hearts fibrillating.
在离体兔心脏中，对电刺激诱发心室颤动进行了进一步观察，这是对之前发现（即从37摄氏度冷却到32摄氏度可使颤动停止）的扩展。目前的观察表明，在37摄氏度时，用洛克溶液灌注的离体兔心脏处于缺氧边缘，但在32摄氏度时，氧气供应充足。在较低温度下，在任何给定钾浓度下发生颤动的心脏比例降低，因此，尽管随着钾浓度降低，发生颤动的心脏比例上升，但即使钾浓度降至正常的四分之一，该比例也不高于67%。钙离子浓度与发生颤动的心脏比例之间的关系从37摄氏度时的双相变化变为32摄氏度时几乎呈直线变化，比例随钙离子浓度升高而增加。证实了钠浓度降低也会提高发生颤动的心脏比例。
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