[各因素对血浆中氟哌啶醇浓度/剂量比值的影响]

[Effect of factors on plasma haloperidol concentration/dose ratio].

作者信息

Ohara Koichi, Shibuya Haruo

机构信息

Clinical Research Institute, National Minami Hanamaki Hospital, Kanagawa Prefectural Center for Psychiatry, 2-5-1 Serigaya, Kohnan, Yokohama, 233-0006 Japan.

出版信息

Nihon Shinkei Seishin Yakurigaku Zasshi. 2003 Aug;23(4):183-6.

PMID:13677914

Abstract

It has been known that the serum concentration of antipsychotics is varied according to individual case. There are several factors that may affect the plasma levels of antipsychotics; e.g., antipsychotic dose, body weight, interaction with other drugs, enzyme activity in the human liver, age and smoking. The enzyme cytochrome P450 2D6 (CYP2D6) is an important factor affecting the plasma levels of antipsychotics, because CYP2D6 is involved in the metabolism of these drugs. In this paper, we review the effect of several factors on plasma haloperidol concentration.

摘要

已知抗精神病药物的血清浓度因个体情况而异。有几个因素可能会影响抗精神病药物的血浆水平，例如抗精神病药物剂量、体重、与其他药物的相互作用、人体肝脏中的酶活性、年龄和吸烟。细胞色素P450 2D6（CYP2D6）酶是影响抗精神病药物血浆水平的一个重要因素，因为CYP2D6参与这些药物的代谢。在本文中，我们综述了几个因素对血浆氟哌啶醇浓度的影响。