一种新型缩肽抗生素，变异肽菌素。
A new depsipeptide antibiotic, variapeptin.
作者信息
Nakagawa M, Hayakawa Y, Adachi K, Seto H
机构信息
Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
出版信息
Agric Biol Chem. 1990 Mar;54(3):791-4.
PMID:1368536
Abstract
A culture similar to Streptomyces variabilis was found to produce a novel cyclic hexadepsipeptide antibiotic named variapeptin. Variapeptin is structurally related to azinothricin, A83586C, and citropeptin. The antibiotic was active against Gram-positive bacteria and showed cytotoxic activity against mammalian cells.
摘要
发现一种类似于可变链霉菌的培养物能产生一种名为变异肽素的新型环状六肽缩酚酸肽抗生素。变异肽素在结构上与氮杂丝氨酸、A83586C和柠檬肽素相关。该抗生素对革兰氏阳性菌有活性，并对哺乳动物细胞表现出细胞毒性活性。
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