Estrada-Aguilar J, Greenberg H, Walling A, Schroer K, Black T, Morse S, Hvizdala E
Department of Pediatrics, H. Lee Moffitt Cancer & Research Institute, University of South Florida, Tampa.
Cancer. 1992 Mar 1;69(5):1137-45. doi: 10.1002/cncr.2820690513.
Five patients, ages 12 to 20 years, with nonresectable primary (Patients 2, 3, and 5) and metastatic (Patients 1 and 4) pelvic osteosarcomas were treated with intraarterial cisplatin and concurrent radiation therapy from 1983 to 1987. Long-term local tumor control was achieved in all five patients. Patients 1 and 3 are alive with no evidence of local recurrence or metastatic disease at 77 and 56 months of follow-up, respectively, since diagnosis of the pelvic tumor. Patients 2, 4, and 5 died of metastatic lung disease at 25, 39, and 12 months, respectively, after diagnosis of the pelvic tumor. Patient 4 had no clinical or radiologic evidence of local recurrence. Control of tumor growth in patients with pelvic osteosarcomas can be achieved with regional chemotherapy and concurrent radiation therapy. These patients also should receive adjuvant intensive systemic chemotherapy to increase the probability of eliminating potential subclinical metastatic disease.
1983年至1987年期间，对5例年龄在12至20岁之间、患有不可切除的原发性（患者2、3和5）和转移性（患者1和4）盆腔骨肉瘤的患者进行了动脉内顺铂治疗并同步放疗。所有5例患者均实现了长期局部肿瘤控制。自盆腔肿瘤诊断以来，患者1和3分别在随访77个月和56个月时存活，无局部复发或转移性疾病证据。患者2、4和5分别在盆腔肿瘤诊断后的25个月、39个月和12个月死于转移性肺病。患者4无局部复发的临床或影像学证据。盆腔骨肉瘤患者可通过区域化疗和同步放疗实现肿瘤生长控制。这些患者还应接受辅助强化全身化疗，以提高消除潜在亚临床转移性疾病的概率。
