Kaik G
Int J Clin Pharmacol Biopharm. 1976 Oct;14(3):177-85.
The bronchodilator effect of intravenously administered drugs was tested by whole bodyplethysmography in 24 patients with chronic obstructive airway disease over a period of 60 min. Subsequent to this, another bronchodilator was applied by a metered dose inhaler. Aminophylline (0,24 g i.v.) was followed by a decrease of airway resistance to a maximum of 73,04% of the base line value after 30 min. and to 76,33% after 60 min; inhalation of fenoterol (0,4 mg) caused a further decrease to 47,33% after 20 min. Diprophylline (0,28 gi.v.) produced only a slight decrease to a maximum of 95,75% after 20 min. and to 99,54% after 60 min.; fenoterol (0,4mg) reduced airway resistance to 55,29%. Hexoprenaline (0,005 mg i.v.) was followed by a decrease to a maximum of 74,71% after 5 min. and to 92,83% after 60 min.; ipratropiumbromide (0,08 mg) caused a further decrease to 54,92%. A considerable increase of heart rate, from 89,25/min. to 106,15/min. occurred only after hexoprenaline. For intravenous bronchodilator therapy we prefer aminophylline. Optimal bronchodilation however, was seen only after further application of fenoterol or ipratropiumbromide by a metered dose inhaler.
通过全身体积描记法对24例慢性阻塞性气道疾病患者静脉注射药物的支气管扩张作用进行了60分钟的测试。在此之后，通过定量吸入器应用另一种支气管扩张剂。静脉注射氨茶碱（0.24g）后，气道阻力在30分钟时降至基线值的73.04%，60分钟时降至76.33%；吸入非诺特罗（0.4mg）后，20分钟时气道阻力进一步降至47.33%。二羟丙茶碱（0.28g静脉注射）仅在20分钟时略有下降，降至最大值95.75%，60分钟时降至99.54%；非诺特罗（0.4mg）使气道阻力降至55.29%。静脉注射海索那林（0.005mg）后，5分钟时气道阻力降至最大值74.71%，60分钟时降至92.83%；异丙托溴铵（0.08mg）使气道阻力进一步降至54.92%。仅在注射海索那林后，心率从89.25次/分钟显著增加到106.15次/分钟。对于静脉支气管扩张剂治疗，我们更倾向于氨茶碱。然而，只有在通过定量吸入器进一步应用非诺特罗或异丙托溴铵后，才能看到最佳的支气管扩张效果。
