大鼠对吗啡的细胞适应性
Cellular adaptation to morphine in rats.
作者信息
TAKEMORI A E
出版信息
Science. 1961 Mar 31;133(3457):1018-9. doi: 10.1126/science.133.3457.1018.
Abstract
The respiration of KCl-stimulated cortical slices of brain from control rats is markedly depressed by morphine, whereas the respiration of those from rats chronically dosed with morphine is unaffected. The results demonstrate an adaptation to morphine at the cellular level which is concomitant with the adaptation of the whole animal to morphine
摘要
氯化钾刺激的正常大鼠脑皮质切片的呼吸，会被吗啡显著抑制，而长期给予吗啡的大鼠的脑皮质切片呼吸则不受影响。这些结果表明，在细胞水平上对吗啡产生了适应性，这与整个动物体对吗啡的适应性是相伴发生的。
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