Ulman L G, Evans H F, Iismaa T P, Potter E K, McCloskey D I, Shine J
Prince of Wales Medical Research Institute, Prince of Wales Hospital, Syndey, Australia.
Neurosci Lett. 1992 Feb 17;136(1):105-8. doi: 10.1016/0304-3940(92)90659-u.
Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequenced. It is of particular interest as it is not C-terminally amidated, unlike porcine and rat GAL. Many regulatory peptides require a C-terminal amide group for their action. However, human GAL showed similar biological activity to the other (amidated) GALs here. Omission of a single amino acid (Ser6) from rat GAL significantly attenuated both cardiovascular actions studied here.
甘丙肽（GAL）分布于猫的交感神经中，外源性甘丙肽可抑制该物种的心脏迷走神经活动并降低血压。这项对麻醉猫的研究比较了人、大鼠和猪甘丙肽对心脏迷走神经活动和血压的影响。人甘丙肽最近才完成测序。它特别引人关注，因为与猪和大鼠甘丙肽不同，它的C末端没有酰胺化。许多调节肽需要C末端酰胺基团才能发挥作用。然而，人甘丙肽在此处显示出与其他（酰胺化）甘丙肽相似的生物学活性。大鼠甘丙肽缺失单个氨基酸（Ser6）会显著减弱此处研究的两种心血管作用。
