Pérez-Otaño I, Herrero M T, Luquin M R, Obeso J A, Del Río J
Department of Pharmacology, University of Navarra Medical School, Pamplona, Spain.
Brain Res. 1992 Jul 10;585(1-2):156-60. doi: 10.1016/0006-8993(92)91201-o.
Common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 1.25-2.5 mg/kg s.c., twice a week) for 5-10 consecutive months. The initial doses of MPTP produced a severe parkinsonian syndrome but motor activity was partially recovered at the end of treatment. Fifteen days or 6 months after the last MPTP dose, monkeys were sacrificed. In addition to a strong decrease of dopamine in the striatum, there were significant reductions in substance P and Met-enkephalin content in the substantia nigra, caudate nucleus and putamen. In the globus pallidus, the reduction in peptide levels did not reach statistical significance as compared to controls. Neurotensin levels were also decreased in the caudate nucleus. The chronic administration of MPTP for 5-10 months induces changes in substance P and Met-enkephalin systems which resemble the degeneration found in brains from parkinsonian patients.
普通狨猴连续5至10个月每周皮下注射两次1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP，1.25 - 2.5毫克/千克）。MPTP初始剂量导致严重的帕金森综合征，但治疗结束时运动活动部分恢复。最后一次注射MPTP后15天或6个月，处死猴子。除纹状体中多巴胺显著减少外，黑质、尾状核和壳核中P物质和甲硫氨酸脑啡肽含量也显著降低。与对照组相比，苍白球中肽水平的降低未达到统计学意义。尾状核中神经降压素水平也降低。连续5至10个月慢性给予MPTP会引起P物质和甲硫氨酸脑啡肽系统的变化，类似于帕金森病患者大脑中发现的退化。
