费尔蒂综合征中淋巴细胞表型和T细胞受体基因型分析。
Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome.
作者信息
Meliconi R, Kingsley G H, Pitzalis C, Sakkas L, Panayi G S
机构信息
Department of Medicine, United Medical School, Guy's Hospital, London, United Kingdom.
出版信息
J Rheumatol. 1992 Jul;19(7):1058-64.
Natural killer (NK) cells and CD3+ large granular lymphocytes (LGL) were investigated in patients with Felty's syndrome (FS), rheumatoid arthritis (RA) and healthy controls. In most patients with FS, NK cell number and activity were decreased. CD3+ LGL were unchanged. However, in one patient a marked expansion of CD3- CD16+ CD56+ (NK) cells was seen and in a second, an expansion of CD3+ LGL. In FS there was also an increase in HLA- DR+ and CD8+ but not gamma delta+ T cells. Three of 11 patients with FS studied demonstrated a dominant rearrangement of the T cell receptor beta gene constant region consistent with oligoclonal T cell expansion.
对费尔蒂综合征（FS）患者、类风湿关节炎（RA）患者及健康对照者的自然杀伤（NK）细胞和CD3⁺大颗粒淋巴细胞（LGL）进行了研究。在大多数FS患者中，NK细胞数量和活性降低。CD3⁺LGL无变化。然而，在1例患者中可见CD3⁻CD16⁺CD56⁺（NK）细胞显著扩增，在另1例患者中CD3⁺LGL扩增。在FS中，HLA - DR⁺和CD8⁺T细胞增加，但γδ⁺T细胞未增加。在研究的11例FS患者中，有3例表现出与寡克隆T细胞扩增一致的T细胞受体β基因恒定区的显性重排。
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