滴滴涕1 MF-2输精管细胞上的核苷酸受体。
Nucleotide receptors on DDT1 MF-2 vas deferens cells.
作者信息
Van der Zee L, Nelemans A, Den Hertog A
机构信息
Department of Pharmacology/Clinical Pharmacology, University of Groningen, Netherlands.
出版信息
Eur J Pharmacol. 1992 May 14;215(2-3):317-20. doi: 10.1016/0014-2999(92)90048-9.
On exposure to triphosphatic nucleotides vas deferens DDT1 MF-2 smooth muscle cells responded with an outward K+ current as measured with the whole-cell patch clamp configuration. The rank order of potency was: ATP greater than UTP greater than TTP greater than CTP = GTP. The responses evoked by these agonists were blocked by suramin. Adenosine, ADP, alpha, beta-methylene-ATP and 2-methylthio-ATP did not affect the transmembrane current. The responses evoked by the nucleotides in DDT1 MF-2 cells are supposed to be mediated via 'nucleotide' receptors.
在暴露于三磷酸核苷酸时，输精管DDT1 MF - 2平滑肌细胞会产生外向钾离子电流，这是通过全细胞膜片钳配置测量得到的。效力顺序为：ATP大于UTP大于TTP大于CTP = GTP。这些激动剂引发的反应被苏拉明阻断。腺苷、ADP、α,β - 亚甲基 - ATP和2 - 甲硫基 - ATP不影响跨膜电流。DDT1 MF - 2细胞中核苷酸引发的反应被认为是通过“核苷酸”受体介导的。
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