WILSON C W
Br J Pharmacol Chemother. 1959 Dec;14(4):415-9. doi: 10.1111/j.1476-5381.1959.tb00944.x.
The occurrence of audiogenic seizures in mice has been used as the basis of a method for measuring the antagonism between sodium thiopentone and bemegride or leptazol. Thiopentone in doses of 8 and 16 mg./kg. protected all the mice against the occurrence of audiogenic seizures. Bemegride and leptazol were administered in doses having molecular concentrations which bore a simple relationship to the doses of thiopentone. Bemegride was four times as powerful as leptazol in antagonizing the protective effect of thiopentone, and comparison of their regression lines showed that both analeptics acted in the same way. The antagonistic effect of bemegride occurred with doses less than its normal convulsant dose, but the doses of leptazol needed to antagonize thiopentone were within the convulsant range, and it increased the severity of any audiogenic seizures.
小鼠听源性惊厥的发生已被用作一种测量硫喷妥钠与美解眠或戊四氮之间拮抗作用方法的基础。8毫克/千克和16毫克/千克剂量的硫喷妥钠可保护所有小鼠不发生听源性惊厥。美解眠和戊四氮的给药剂量，其分子浓度与硫喷妥钠的剂量存在简单关系。在拮抗硫喷妥钠的保护作用方面，美解眠的效力是戊四氮的四倍，对它们回归线的比较表明，两种苏醒药的作用方式相同。美解眠的拮抗作用在低于其正常惊厥剂量时就会出现，但拮抗硫喷妥钠所需的戊四氮剂量处于惊厥范围内，并且它会增加任何听源性惊厥的严重程度。
